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| Sarto,Danielle Aparecida Quintino Silva; Siqueira,Ana Helena D’Arcadia de; Magalhaes,Francisco Monteiro de Almeida; Caproni,Karine de Paula; Martins,Ângela Maria; Santos,Gérsika Bitencourt; Silva,Délcio Bueno da; Boas,Brígida Monteiro Vilas; Garcia,José Antônio Dias. |
| ABSTRACT The control of dyslipidemia by using herbal products is an important subject for studies. In this study, we evaluated the effects of dry Passiflora incarnata L. extract over dyslipidemia, left ventricular hypertrophy, and hepatic oxidative stress of LDL receptor knockout mice (LDLr-/-). Forty 4-month old male LDLr-/- mice were distributed into four groups: Group standard diet; Group standard diet and 200 mg/kg of body weight of Passiflora incarnata L. leaf dry extract; Group high-fat diet; Group high-fat diet and 200 mg/kg of body weight of Passiflora incarnata L. leaf dry extract. After 30 days, Passiflora incarnata L. dry extract reduced the effects of the high-fat diet, with a decrease of total cholesterol, triglycerides, and increase of... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Passion fruit; Left ventricular hypertrophy; Dyslipidemia; Oxidative stress. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132018000100321 |
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| Kaneto,C.M.; Nascimento,J.S.; Moreira,M.C.R.; Ludovico,N.D.; Santana,A.P.; Silva,R.A.A.; Silva-Jardim,I.; Santos,J.L.; Sousa,S.M.B.; Lima,P.S.P.. |
| Recent evidence suggests that cell-derived circulating miRNAs may serve as biomarkers of cardiovascular diseases. However, a few studies have investigated the potential of circulating miRNAs as biomarkers for left ventricular hypertrophy (LVH). In this study, we aimed to characterize the miRNA profiles that could distinguish hypertensive patients with LHV, hypertensive patients without LVH and control subjects, and identify potential miRNAs as biomarkers of LVH. LVH was defined by left ventricular mass indexed to body surface area >125 g/m2 in men and >110 g/m2 in women and patients were classified as hypertensive when presenting a systolic blood pressure of 140 mmHg or more, or a diastolic blood pressure of 90 mmHg or more. We employed miRNA PCR... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cardiovascular disease; Hypertension; Left ventricular hypertrophy; MicroRNAs. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017001200605 |
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| Plavnik,F.L.; Silva,M.A.M.R.T.; Kohlmann,N.E.B.; Kohlmann Jr.,O.; Ribeiro,A.B.; Zanella,M.T.. |
| The aim of this study was to determine the relationship between urinary albumin excretion (UAE), cardiac structural changes upon echocardiography and 24-h ambulatory blood pressure (ABPM) levels. Twenty mild hypertensive patients (mean age 56.8 ± 9.6 years) were evaluated. After 2 weeks of a washout period of all antihypertensive drugs, all patients underwent an echocardiographic evaluation, a 24-h ABPM and an overnight urine collection. Systolic and diastolic blood pressure during 24-h ABPM was 145 ± 14/91 ± 10 mmHg (daytime) and 130 ± 14/76 ± 8 mmHg (nighttime), respectively. Seven (35%) patients presented UAE > or = 15 µg/min, and for the whole group, the geometric mean value for UAE was 10.2 x/÷ 3.86 µg/min. Cardiac measurements showed mean values... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hypertension; Microalbuminuria; Left ventricular hypertrophy; Blood pressure monitoring. |
| Ano: 2002 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000700006 |
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| Cardoso,R.L.; Nogueira,A.R.; Salis,L.H.A.; Ürményi,T.P.; Silva,R.; Moura-Neto,R.S.; Pereira,B.B.; Rondinelli,E.; de Souza e Silva,N.A.. |
| Our aim was to determine the frequencies of the angiotensin-converting enzyme (ACE) gene alleles D and I and any associations to cardiovascular risk factors in a population sample from Rio de Janeiro, Brazil. Eighty-four adults were selected consecutively during a 6-month period from a cohort subgroup of a previous large cross-sectional survey in Rio de Janeiro. Anthropometric data and blood pressure measurements, echocardiogram, albuminuria, glycemia, lipid profile, and ACE genotype and serum enzyme activity were determined. The frequency of the ACE*D and I alleles in the population under study, determined by PCR, was 0.59 and 0.41, respectively, and the frequencies of the DD, DI, and II genotypes were 0.33, 0.51, and 0.16, respectively. No association... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Angiotensin-converting enzyme gene polymorphism; Left ventricular hypertrophy; Angiotensin-converting enzyme activity; Albuminuria; Hypertension. |
| Ano: 2008 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000600013 |
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| Randon,R.B.; Rohde,L.E.; Comerlato,L.; Ribeiro,J.P.; Manfro,R.C.. |
| End-stage renal disease (ESRD) patients frequently develop structural cardiac abnormalities, particularly left ventricular hypertrophy (LVH). The mechanisms involved in these processes are not completely understood. In the present study, we evaluated a possible association between parathyroid hormone (PTH) levels and left ventricular mass (LVM) in patients with ESRD. Stable uremic patients on intermittent hemodialysis treatment were evaluated by standard two-dimensional echocardiography and their sera were analyzed for intact PTH. Forty-one patients (mean age 45 years, range 18 to 61 years), 61% males, who had been on hemodialysis for 3 to 186 months, were evaluated. Patients were stratified into 3 groups according to serum PTH: low levels (<100 pg/ml;... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: End-stage renal failure; Parathyroid hormone; Echocardiography; Left ventricular hypertrophy. |
| Ano: 2005 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000900016 |
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